Anthropometry, nutrient intake, serum levels of lipids and response areas of glucose, C-peptide, and free fatty acid (FFA) during oral glucose tolerance test (OGTT) were estimated on 113 (66 male, 47 female) nonobese NIDDM and 23 (4 male, 19
female)
obses NIDDM patients. The waist-hip ratio (W/H) correlated significantly and positively with serum insulin response area during OGTT in male diabetics, and plasma levels of glucose at fasting and 2 hours after meal, serum levels of total
cholesterol and
triglyceride, and the response areas of C-peptide, insulin and free fatty acid during OGTT in female diabetics. Two groups, one group of W/H more than 1 (W/H≥1) and the other group of W/H less than 1( w/H<1), were compared in each sex to
investigate
the effect of body fat distribution on glucose tolerance and serum lipids. Percent ideal body weight (%IBW), even within the normal range, and insulin response area during OGTT were greater in the male diabetics of W/H≥1 than the group of W/H<1.
Percent IBW within the overweight range, serum levels of total cholesterol and triglyceride, and response areas of insulin, C-peptide and free fatty acid during OGTT were greater in the female diabetics of W/H≥1 compared to the group of W/H<1.
Increased calorie intake and decreased physical activity in female diabetics of W/H ≥1 could explain the overweight close to obese with central fat localization. Our results indicate that central fat distribution even in normal range of body
weight can
cause hyperinsulinemia and central obesoty can worsen hyperinsulinemia, and hyperlipidemia in NIDDM patients.
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